Snail2–PHD12 interaction recruits an epigenetic repressive complex that mediates neural crest epithelial–mesenchymal transition
نویسندگان
چکیده
منابع مشابه
A PHD12–Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
Neural crest cells form within the neural tube and then undergo an epithelial to mesenchymal transition (EMT) to initiate migration to distant locations. The transcriptional repressor Snail2 has been implicated in neural crest EMT via an as of yet unknown mechanism. We report that the adaptor protein PHD12 is highly expressed before neural crest EMT. At cranial levels, loss of PHD12 phenocopies...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2011
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2011.05.498